Mutagenesis – There are several published reports on the potential genetic toxicity of methadone. Methadone tested negative in tests for chromosome breakage and disjunction and sex-linked recessive lethal gene mutations hinein germ cells of Drosophila using feeding and injection procedures.
Methadone should be given with caution and the initial dose reduced rein certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death. Patients and caregivers should Beryllium instructed to keep methadone in a secure place out of the reach of children and to discard unused methadone rein such a way that individuals other than the patient for whom it was originally prescribed will not come rein contact with the drug.
Methadone-maintained patients beginning treatment with these antiretroviral drugs should be monitored for evidence of withdrawal effects and methadone dose should Beryllium adjusted accordingly.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result in withdrawal symptoms. Your doctor may change your dosage of methadone as needed.
Abnormal fetal nonstress tests (NSTs) have been reported to occur more frequently when the test is performed 1 to 2 hours after a maintenance dose of methadone in late pregnancy compared to controls.
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Several studies have suggested that infants born to narcotic-addicted women treated with methadone during all or part of pregnancy have been found to have decreased fetal growth with reduced birth weight, length, and/or head circumference compared to controls.
Rein using methadone an individualized benefit to risk assessment should be carried out and should include evaluation of patient presentation and complete medical history.
Certified treatment programs shall dispense and use methadone rein oral form only and according to the treatment requirements stipulated rein the Federal Opioid Treatment Standards (42 CFR 8.12). Weiher below for important regulatory exceptions to the general requirement for certification to provide opioid agonist treatment.
Typically, your doctor will Keimzelle you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
Clinical studies of methadone did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently compared to younger subjects. Other reported clinical experience has not identified differences rein responses between elderly and younger patients.
Methadone should Beryllium administered with particular caution to patients already at risk for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia). Careful monitoring is recommended when using methadone hinein patients with a history of cardiac conduction abnormalities, those taking medications affecting cardiac conduction, and in other cases where history or physical exam suggest an increased risk of dysrhythmia. QT prolongation has also been reported hinein patients with no prior cardiac history Weltgesundheitsorganisation have received high doses of methadone.